D3S

We specialized in the application of our innovative D3S technology in our biomaterials.

SF Gel

Silk fibroin gel, minimum fibroin content 2%.

Applications for cell encapsulation and drug delivery.
Injectable format for in situ gelation.

SF-A Gel

Silk fibroin gel functionalized with alkyne/azide, fibroin content >2%.

Applications for cell encapsulation and drug delivery.
Injectable format for in situ gelation. Stable binding between cells and drugs and gel through cross-linking.

SF-S Gel

Silk fibroin gel functionalized with sulfhydryl groups, fibroin content >2%.

Applications for cell encapsulation and drug delivery.
Injectable format for in situ gelation. Stable binding between cells and drugs and gel through cross-linking.

• D3S

SF-D3S Fiber

Silk fibroin fiber made by D3S, ⏀ <10 μm.

Applications for sutures and tendon and ligament substitutes. Support fibers for fibrillar tissue scaffolds.

SF-D3S-S Fiber

Silk fibroin fiber made by D3S, functionalized with sulfhydryl groups.

Applications for tissue scaffolds with specific interaction with the indicated cell lines. Axonal reconnection.

SF-D3S-A Fiber

Silk fibroin fiber made by D3S, functionalized with alkyne/azide.

Applications for tissue scaffolds with specific interaction with the indicated cell lines. Axonal reconnection.

• Electrospinning

SF-ES Fiber

Produced by electrospinning, yielding fibers ⏀ <10 μm.

SF-ES-S Fiber

Silk fibroin fiber made by electrospinning, functionalized with sulfhydryl groups.

SF-ES-A Fiber

Silk fibroin fiber made by electrospinning, functionalized with alkyne/azide.

• Decorated Fibers

SF-D3S Fiber for Blood Vessel Formation

Fibrillar substrates functionalized with biomolecules, to create vasculature and microvasculature of arbitrary geometriesS, ⏀ <10 μm.

Hybrid STub scaffolds Tubular scaffolds, functionalized/non-functionalized, integrated with Schwann cells for peripheral nerve regeneration.

• D3S

SF-D3S Mesh

Silk fibroin mesh made by D3S, density 0.2g/cm2.

Applications as a 2D cell substrate for tissue engineering.

SF-D3S-A Mesh

Silk fibroin mesh made by D3S functionalized with alkyne/azide, density 0.2g/cm2.

Applications as a 2D cell substrate with specific interaction with the indicated cell lines.

SF-D3S-S Mesh

Silk fibroin mesh made by D3S functionalized with sulfhydryl groups, density 0.2g/cm2.

Applications as a 2D cell substrate for tissue engineering.

• Electrospinning

SF-ES Mesh

Silk fibroin mesh made by electrospinning, density 0.2g/cm2. Applications as a 2D cell substrate for tissue engineering.

SF-ES-S Mesh

Silk fibroin mesh made by electrospinning functionalized with sulfhydryl groups, density 0.2g/cm2.

Applications as a 2D cell substrate with specific interaction with the indicated cell lines.

SF-ES-A Mesh

Silk fibroin mesh made by electrospinning functionalized with alkyne/azide, density 0.2g/cm2.

Applications as a 2D cell substrate with specific interaction with the indicated cell lines.

• Decorated Meshes

Bruch's Membranes

Silk fibroin Bruch membranes that facilitate the formation of the retinal pigment epithelium and blood vessels on their opposite sides. It also facilitates the creation of a blood-retinal barrier.

Commercialized by Human Retina SL.

We offer the possibility to order complete customized decorated meshes.

SF-Film

Silk fibroin made by water annealing, density 0.2g/cm2.

Applications as a 2D substrate in tissue engineering and in organ-on-a-chip format.

• Functionalized Films

SF-Film-S 

Silk fibroin film manufactured by water annealing functionalized with sulfhydryl groups, density 0.2g/cm2.

Applications as a 2D substrate in tissue engineering and in organ-on-a-chip format with specific interaction for indicated cell lines.

SF-Film-A

Silk fibroin film manufactured by water annealing functionalized with alkyne/azide, density 0.2g/cm2.

Applications as a 2D substrate in tissue engineering and in organ-on-a-chip format with specific interaction for indicated cell lines.

• Decorated Films

Bruch's Membranes

Silk fibroin Bruch membranes that facilitate the formation of the retinal pigment epithelium and blood vessels on their opposite sides. It also facilitates the creation of a blood-retinal barrier.

Commercialized by Human Retina SL.

We offer the possibility to order complete customized decorated meshes.

SF-D3S Tubular Scaffolds

Silk fibroin tubular scaffolds manufactured by D3S, internal ⏀ 0.1-2.0mm.

Applications for connection with vessels of the circulatory system with controlled permeability. Applications for regeneration of nerve connections.

Configuration: uni or bi-tubular.

• Functionalized Tubular Scaffolds

SF-D3S-Tub-S Scaffolds

Silk fibroin tubular scaffolds manufactured by D3S, internal ⏀ 0.1-2.0mm, functionalized by sulfhydryl groups with peptides and/or neurotrophic factors.

Applications for connection with vessels of the circulatory system with controlled permeability. Applications for regeneration of nerve connections. Specific interaction with endothelial and nervous system cells. Controlled release of growth factors.

Configuration: uni or bi-tubular.

SF-D3S-Tub-A Scaffolds

Silk fibroin tubular scaffolds manufactured by D3S, internal ⏀ 0.1-2.0mm, functionalized with peptides or neurotrophic factors by alkyne/azide.

Applications for connection with vessels of the circulatory system with controlled permeability. Applications for regeneration of nerve connections. Specific interaction with endothelial and nervous system cells. Controlled release of growth factors.

Configuration: uni or bi-tubular.

• Decorated Tubular Scaffolds

Hybrid SF-D3S-Tub Bi-tubular Scaffolds

Double-tube scaffolds, functionalized or not, integrated with Schwann cells, with separate sensory and motor phenotypes, for differentiated regeneration of peripheral nerves.

We offer the possibility to order complete customized decorated tubular scaffolds.

SILKforBRAIN

Minimally inasive stroke therapy (silk hidrogels + mesenchymal stem cells).

SILK-ELM

Minimally invasive therapy (silk hydrogels + bacteria).

In development process, financed and supported by the Pathfinder European Project ISOS.